SIGNAL-ON: Selective Induced Generation of New Active species using Light, Organocatalysis, and flow techNology
PIANO NAZIONALE DI RIPRESA E RESILIENZA (PNRR)
Missione 4 “Istruzione e Ricerca” - Componente C2
Investimento 1.1, “Fondo per il Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN)”
Codice progetto: P2022YM7F2
CUP: E53D23016160001
Contributo MUR per Ricerca: 246.545 euro
Cofinanziamento Ateneo/Ente: 92.000 euro
Partners
- Università degli Studi dell’AQUILA (Unità), Responsabile: Armando Carlone
- Università di Basi (Capofila), Responsabile: Renzo Luisi
- Università di Cagliari (Unità), Responsabile: Francesco Secci
Brief description and main objectives
Sviluppo di processi catalitici sostenibili (fotocatalisi e organocatalisi) per la generazione controllata di specie reattive in sistemi a flusso continuo. L'integrazione di queste tecnologie mira a massimizzare l'efficienza delle reazioni e la sicurezza operativa, riducendo drasticamente la produzione di scarti chimici e l'impatto ambientale complessivo rispetto ai metodi tradizionali.
Main results and publications
Ottimizzazione di reazioni fotochimiche mirate, identificazione di reazioni organocatalitiche selettive e implementazione di tecnologie "flow chemistry" per la sostenibilità e l'efficienza dei processi sintetici.
Reclutamento e formazione di 2 ricercatori post-doc specializzati; pubblicazione di articoli scientifici su testate internazionali di settore (l'elenco completo è disponibile nella Relazione Finale); attività di outreach e public engagement.
Pubblicazioni
Elenco delle pubblicazioni scientifiche derivanti dalle attività di ricerca del progetto.
1. Low-Impact Synthesis of γ-Lactones through Photoinduced Baeyer-Villiger Oxidation of Cyclic Ketones, https://doi.org/10.1002/ejoc.202400226 (open access) Eur. J. Org. Chem.
2. Catalytic Enantioselective Synthesis of Conformationally Stable C(sp2)−C(sp3) Naphthocoumarin Atropisomers (open access), Adv. Synth. Catal.
3. Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones, https://doi.org/10.1039/D4CC04089A. (open access) Chem Commun
4. For the development and characterization of photoactive coumarin dyes see: 3D-printed optical VOC sensors based on donor-substituted coumarin TADF emitters, https://doi.org/10.26434/chemrxiv.10001624/v1 (open access) Chem Rxiv.
5. A straightforward route to substituted 1-pyrrolines via photocatalyzed ring-opening cyclization of cyclopropyl enamines, https://doi.org/10.21203/rs.3.rs-7932387/v1, (open access) Research Square
6. Enantiopurity-Dependent Peptide Coacervates and Asymmetric Organocatalysis, https://doi.org/10.1002/smll.202514872, (Open Access)
7. Small Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors, https://doi.org/10.1002/chem.202500126, (Open Access), Chemistry – A European Journal
8. A Practical and Scalable Enantioselective Synthesis of (S)-Autumnaline, https://doi.org/10.26434/chemrxiv-2025-dblx9, (Open Access), ChemRxiv
9. A Subtle Twist: Hantzsch Ester-Controlled Enantiodivergence Driven by Weak Non-Covalent Interactions, https://doi.org/10.26434/chemrxiv-2025-9zwv9, (Open Access), ChemRxiv
10. Latest Approaches in Enantiodivergent Organocatalysis, https://doi.org/10.26434/chemrxiv.15001164/v1 , (Open Access), ChemRxiv
11. Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines https://pubs.acs.org/doi/10.1021/jacs.5c10372 J. Am. Chem. Soc. 2025, 147, 39, 35567–35575 (Open Acess)
12. A Novel and Sustainable Continuous-Flow Approach to Atom Deletion and Insertion by Electrophilic Nitrogen Transfer, Green Chemistry, 2026, Under evaluation.
13. Single-Atom Logic Enables Conversion of Cyclopropenes into Cyclobutenes: Access to Oxaspiro[2.3]hexenes, Chem. Sci. 2026, Under evaluation
Reclutamento e formazione di 2 ricercatori post-doc specializzati; pubblicazione di articoli scientifici su testate internazionali di settore (l'elenco completo è disponibile nella Relazione Finale); attività di outreach e public engagement.
Pubblicazioni
Elenco delle pubblicazioni scientifiche derivanti dalle attività di ricerca del progetto.
1. Low-Impact Synthesis of γ-Lactones through Photoinduced Baeyer-Villiger Oxidation of Cyclic Ketones, https://doi.org/10.1002/ejoc.202400226 (open access) Eur. J. Org. Chem.
2. Catalytic Enantioselective Synthesis of Conformationally Stable C(sp2)−C(sp3) Naphthocoumarin Atropisomers (open access), Adv. Synth. Catal.
3. Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones, https://doi.org/10.1039/D4CC04089A. (open access) Chem Commun
4. For the development and characterization of photoactive coumarin dyes see: 3D-printed optical VOC sensors based on donor-substituted coumarin TADF emitters, https://doi.org/10.26434/chemrxiv.10001624/v1 (open access) Chem Rxiv.
5. A straightforward route to substituted 1-pyrrolines via photocatalyzed ring-opening cyclization of cyclopropyl enamines, https://doi.org/10.21203/rs.3.rs-7932387/v1, (open access) Research Square
6. Enantiopurity-Dependent Peptide Coacervates and Asymmetric Organocatalysis, https://doi.org/10.1002/smll.202514872, (Open Access)
7. Small Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors, https://doi.org/10.1002/chem.202500126, (Open Access), Chemistry – A European Journal
8. A Practical and Scalable Enantioselective Synthesis of (S)-Autumnaline, https://doi.org/10.26434/chemrxiv-2025-dblx9, (Open Access), ChemRxiv
9. A Subtle Twist: Hantzsch Ester-Controlled Enantiodivergence Driven by Weak Non-Covalent Interactions, https://doi.org/10.26434/chemrxiv-2025-9zwv9, (Open Access), ChemRxiv
10. Latest Approaches in Enantiodivergent Organocatalysis, https://doi.org/10.26434/chemrxiv.15001164/v1 , (Open Access), ChemRxiv
11. Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines https://pubs.acs.org/doi/10.1021/jacs.5c10372 J. Am. Chem. Soc. 2025, 147, 39, 35567–35575 (Open Acess)
12. A Novel and Sustainable Continuous-Flow Approach to Atom Deletion and Insertion by Electrophilic Nitrogen Transfer, Green Chemistry, 2026, Under evaluation.
13. Single-Atom Logic Enables Conversion of Cyclopropenes into Cyclobutenes: Access to Oxaspiro[2.3]hexenes, Chem. Sci. 2026, Under evaluation
